Stimulation of the thyroid gland with TSH A) Causes the thyroid cells to become flattened B) Causes the thyroid cells to become more columnar C) Decreases the size of the follicles because they consume the colloid D) Uses a G_q mechanism to stimulate thyroxine secretion E) Involves direct m anipulation of TSH-response elements in the follicular cells

Question

Quizplus · Accepted Answer

TSH binds to receptors on the basal surface of thyroid follicular cells, activating a G_s protein that stimulates adenylyl cyclase to produce cAMP. cAMP activates protein kinase A, which phosphorylates thyroglobulin and other proteins, leading to increased synthesis and secretion of thyroxine.

Stimulation of the Thyroid Gland with TSH