Which of the following is an example of central hypothyroidism?
A) Lack of iodine in the diet
B) Defect in NIS
C) Defect in pendrin
D) Malfunctioning thyroid peroxidase
E) Defects in the TRH receptor

Question

Quizplus · Accepted Answer

Central hypothyroidism is caused by a failure in the hypothalamus or pituitary gland, not directly by the thyroid gland itself. A defect in the TRH (Thyrotropin-Releasing Hormone) receptor fits this description, as TRH is produced by the hypothalamus to stimulate the pituitary gland to release TSH (Thyroid-Stimulating Hormone), which in turn stimulates the thyroid gland. Defects in the TRH receptor would impair this signaling pathway, leading to central hypothyroidism.

Which of the Following Is an Example of Central Hypothyroidism