Which of the following is true regarding comparison of the physical maps and recombination maps?
A) Only with recent genome sequence analysis, which compares physical and recombination maps, has it been possible to determine that recombination hotspots are distributed evenly throughout the Drosophila genome.
B) Map distances calculated by recombination frequencies can underestimate the physical distance between two genes.
C) There is a linear relationship between recombination frequency and physical distance if the genes are separated by more than 50 cM.
D) Two genes with a coldspot between them have larger recombination frequencies than predicted by their physical distances.
E) Two genes with a hotspot between them have smaller recombination frequencies than predicted by their physical distances.

Question

Quizplus · Accepted Answer

Map distances calculated by recombination frequencies can underestimate the physical distance between two genes because recombination frequency does not always increase linearly with physical distance, especially over large distances or in regions with low recombination rates.

Which of the Following Is True Regarding Comparison of the Physical