After analysis of 100 pedigrees, the Zmax from the analysis of linkage between a disease gene D and the DNA marker P was found to be - 2.5 at 0 = 0.01. Which of the following is the best interpretation of these results?
A) The evidence supports linkage of D and P at 1.0 cM.
B) The evidence indicates that D and P are not linked.
C) The evidence supports linkage of D and P at 10 cM.
D) No conclusion can be made regarding linkage of D and P.
E) The evidence supports linkage of D and P at 0.1 cM.

Question

Quizplus · Accepted Answer

The Zmax value of -2.5 indicates a lack of linkage between the disease gene D and the DNA marker P, especially at a recombination fraction (θ) of 0.01, which suggests that they are not closely linked on the chromosome.

After Analysis of 100 Pedigrees, the Zmax from the Analysis