After analysis of 100 pedigrees, the Zmax from the analysis of linkage between a disease gene D and the DNA marker P was found to be 3.5 at 0 = 0.25. Which of the following is the best interpretation of these results?
A) The evidence indicates that D and P are not linked.
B) The evidence supports linkage of D and P at 0.25 cM.
C) The evidence supports linkage of D and P at 2.5 cM.
D) No conclusion can be made regarding linkage of D and P.
E) The evidence supports linkage of D and P at 25 cM.

Question

Quizplus · Accepted Answer

A Zmax of 3.5 indicates significant evidence for linkage, and a recombination fraction (θ) of 0.25 suggests that the genes are linked at 25 cM.

After Analysis of 100 Pedigrees, the Zmax from the Analysis