Mean platelet volume (MPV) in humans increases with heart attacks and strokes and is used to predict recurrence as well as mortality. MPV has high heritability. A recent GWA study found MPV to be associated with SNPs on chromosomes 12, 3, and 17, respectively. These three QTLs accounted for 4- 5% of MPV variance. Which of the following is a reasonable explanation?
A) Other loci may also account for significant variance of MPV.
B) The three SNPs, when sequenced, should show high conservation.
C) Monitoring of these SNPs should identify those at highest risk.
D) These SNPs must be translocated or transposed alleles.
E) The three SNPs will be found in genes responsible for stroke.

Question

Quizplus · Accepted Answer

Given that the identified SNPs account for only 4-5% of the MPV variance, it is reasonable to conclude that other genetic loci might also contribute significantly to the variance observed in MPV. This suggests a polygenic trait with multiple genetic factors influencing the phenotype.

Mean Platelet Volume (MPV) in Humans Increases with Heart Attacks