The Developmental Variation in Phase I Enzymes Has What Impact

The developmental variation in phase I enzymes has what impact on pediatric prescribing?

A) None, phase I enzymes are stable throughout childhood.
B) Children should always be prescribed lower than adult doses per weight due to low enzyme activity until puberty.
C) Children should always be prescribed higher than adult doses per weight due to high enzyme activity.
D) Prescribing dosages will vary based on the developmental activity of each enzyme, at times requiring lower than adult doses and at other times higher than adult doses based on the age of the child.