A Client Reports Taking Acetaminophen to Control Osteoarthritis

A client reports taking acetaminophen to control osteoarthritis. Which instruction should the nurse give the client requiring long-term acetaminophen use?

A) Caution the client against combining acetaminophen with alcohol.
B) Inform the client that acetaminophen increases the risk for bleeding.
C) Advise taking acetaminophen with meals to prevent gastric irritation.
D) Explain that physical dependence may occur with long-term oral use.