By which mechanism do selective serotonin reuptake inhibitors (SSRI)improve depression?

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Quizplus · Accepted Answer

Depression is thought to be related to lowered availability of the neurotransmitter serotonin.SSRIs act by blocking reuptake of serotonin,leaving a higher concentration available at the synaptic cleft.SSRIs prevent destruction of serotonin.SSRIs have little or no effect on acetylcholine and dopamine production.SSRIs do not produce muscarinic or a₁ norepinephrine blockade.

By Which Mechanism Do Selective Serotonin Reuptake Inhibitors (SSRI)improve Depression