Why should lithium diisopropylamide (LDA) be used in enolate alkylation reactions?
A) LDA completely converts one equivalent of carbonyl to enolate.
B) LDA is too bulky to act as a nucleophile.
C) Lithium complexation with the enolate oxygen can reduce O-alkylation.
D) LDA will selectively remove the least hindered protons from the carbonyl.
E) All these reasons are valid.
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