Which of the following features is a requirement for ligand-mediated dimerization?
A)The ligand has only one binding site for receptors.
B)The ligand has two binding sites for receptors.
C)The receptor must have a phenylalanine residue in a specific location.
D)The receptor must have a molecular weight of 50,000 daltons.
E)Ligand binding causes a conformational shift that reveals a binding site for another receptor.

Question

Quizplus · Accepted Answer

Ligand-mediated dimerization requires a ligand with two binding sites for receptors, allowing for cross-linking of two receptor molecules. A single binding site would not be sufficient for dimerization. The other choices (C and D) are specific to certain receptors and not necessarily general requirements for ligand-mediated dimerization. Choice E refers to induced-fit dimerization, which is a different mechanism than ligand-mediated dimerization.

Which of the Following Features Is a Requirement for Ligand-Mediated