Which of the following supports the ligand-mediated model of receptor dimerization?
A)Some growth and differentiation factors like PDGF or CSF-1 are composed of two similar or identical disulfide-linked subunits, each of which has a binding site for a receptor.
B)Ligands have been found to be proteins that usually dimerize.
C)Ligands have been found to be steroid hormones.
D)Ligands were found to bind to each other.
E)Receptors have been shown to have multiple binding sites for ligands.

Question

Quizplus · Accepted Answer

Option A states that growth and differentiation factors like PDGF or CSF-1 are composed of two similar or identical disulfide-linked subunits, each of which has a binding site for a receptor. This supports the ligand-mediated model of receptor dimerization, as it suggests that ligands can bring together two receptor molecules to form a dimer through binding to the two binding sites on each receptor.

Which of the Following Supports the Ligand-Mediated Model of Receptor