Which type of gene or DNA sequence would you predict to contribute most significantly to the phenomenon of epistasis?

Question

Quizplus · Accepted Answer

Epistasis refers to the phenomenon where the expression of one gene masks or modifies the expression of another gene. Transcription factors play a significant role in regulating gene expression, and therefore, mutations or variations in genes encoding transcription factors are likely to contribute greatly to epistasis. Genes encoding single enzymes or neurotransmitters may also contribute to modifications in gene expression, but their impact may not be as significant as that of transcription factors. Noncoding SNP regions do not encode proteins and may not have a direct role in regulating gene expression or epistasis.

Which Type of Gene or DNA Sequence Would You Predict