Cells are infected with a virus carrying a temperature-sensitive mutant VSVG gene that encodes a protein that cannot leave the ER of infected cells grown at restrictive temperatures (40^oC). Thus, at higher temperatures: A)VSVG protein heads immediately for the Golgi complex. B)VSVG protein cannot leave the ER. C)VSVG protein leaves the ER immediately. D)all of the manufactured VSVG protein leaves the ER synchronously. E)VSVG protein is degraded rapidly and never passes to the Golgi complex.

Question

Quizplus · Accepted Answer

The statement says that the mutant VSVG protein cannot leave the ER of infected cells grown at restrictive temperatures. Therefore, at higher temperatures, the mutant VSVG protein still cannot leave the ER, as it is dependent on the permissive temperature to exit the ER and go to the Golgi complex.

Cells Are Infected with a Virus Carrying a Temperature-Sensitive Mutant