What happens to a newly synthesized glycoprotein after the binding of calnexin or calreticulin
A)When the glycoprotein's folding is correctly completed, the remaining glucose on its oligosaccharide chain is eventually reduced and the glycoprotein is released from the chaperone.
B)The oligosaccharide and amino acid chain are totally degraded.
C)Correct folding of the glycoprotein is prevented until the chaperone is removed.
D)When the glycoprotein's folding is correctly completed, the remaining glucose on its oligosaccharide chain is removed enzymatically and the glycoprotein is released from the chaperone.

Question

Quizplus · Accepted Answer

After the binding of calnexin or calreticulin, the glycoprotein undergoes correct folding assisted by the chaperones. Once the folding is completed, the remaining glucose on the oligosaccharide chain is removed enzymatically by the glucosidase I and II enzymes. This leads to the release of the correctly folded glycoprotein from the chaperones.

What Happens to a Newly Synthesized Glycoprotein After the Binding