What initially happens if misfolded proteins are generated in the ER at a faster rate than they can be exported to the cytoplasm?
A)They are degraded in the ER.
B)They are inserted into the ER membrane.
C)They are resynthesized in the ER.
D)They accumulate in the ER.
E)They accumulate in the Golgi complex.

Question

Quizplus · Accepted Answer

If misfolded proteins are generated in the ER at a faster rate than they can be exported to the cytoplasm, they will accumulate in the ER. This can cause ER stress, which activates a signaling pathway called the unfolded protein response (UPR) to try and restore protein folding homeostasis. If the UPR is unsuccessful, the misfolded proteins can aggregate and lead to cell death.

What Initially Happens If Misfolded Proteins Are Generated in the ER