I-cell disease is typified by __________.
A)lysosomes bloated with undegraded materials
B)the production of normal levels of lysosomal enzymes without the mannose 6-phosphate residues normally present
C)lysosomal enzymes being secreted by the cell because they have not been targeted to lysosomes
D)a deficiency in N-acetylglucosamine phosphotransferase
E)all of these are correct

Question

Quizplus · Accepted Answer

I-cell disease is characterized by all of the mentioned features: lysosomes filled with undegraded materials due to the improper targeting of lysosomal enzymes, which are normally marked by mannose 6-phosphate residues for lysosomal delivery. The deficiency in N-acetylglucosamine phosphotransferase is the underlying cause, leading to the enzymes being secreted outside the cell instead of being directed to the lysosomes.

I-Cell Disease Is Typified by __________