Why would a transverse diffusion or flip-flop of membrane phospholipids from one leaflet to the other be so rare?
A) Flippases are enzymes which are transiently stable and expressed at low concentrations.
B) For flip-flop to occur, it would be necessary for the hydrophilic head of a phospholipid to move through the hydrophobic part of the bilayer, an extremely unlikely event.
C) For flip-flop to occur, it would be necessary for the hydrophobic head of a phospholipid to move through the hydrophilic part of the bilayer, an extremely unlikely event.
D) Other membrane activities like flexing and lateral shift inhibit phospholipid flip-flop.
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