In the Reaction a + B <-> C + D $\Delta$

In the reaction A + B <-> C + D, how might the reaction take place in the cell if the $\Delta$ G is very positive?

A) The reaction would probably take place by coupling it to a reaction with a larger - $\Delta$ G so that when the $\Delta$ G values are added up the sum is negative.
B) The reaction would probably take place by coupling it to a reaction with a smaller - $\Delta$ G so that when the $\Delta$ G values are added up the sum is positive.
C) The reaction would probably take place by coupling it to a reaction with a larger $\Delta$ G so that when the $\Delta$ G values are added up the sum is positive.
D) The reaction would probably take place by coupling it to a reaction with the same positive $\Delta$ G so that when the $\Delta$ G values are added up the energy levels balance.