Which of These Factors or Observations Provide Explanations of How

Which of these factors or observations provide explanations of how the self-assembly of complex structures such as ribosomal subunits can be achieved more efficiently within cells than in vitro? (Select all that apply)

A) prokaryotic cells have been seen to require the participation of transiently associated proteins
B) aqueous phase separation occurs in vivo, but not in vitro
C) many proteins associated with RNA readily form cytoplasmic phase-separated droplets within cytoplasm
D) Rbfox's intrinsically disordered domain appears crucial for both aqueous phase separation and RNA splicing function.