Sutherland discovered that epinephrine signals
A) a decrease in levels of cAMP as a result of bypassing the plasma membrane.
B) lower blood glucose by binding to liver cells.
C) interactions with insulin inside muscle cells.
D) interactions directly with glycogen phosphorylase.
E) elevation of cytosolic concentrations of cyclic AMP.

Question

Quizplus · Accepted Answer

Sutherland discovered that epinephrine signals the elevation of cytosolic concentrations of cyclic AMP. This occurs because epinephrine activates the G protein-coupled adrenergic receptors on the plasma membrane of target cells, leading to the activation of adenylate cyclase and subsequent production of cyclic AMP within the cytosol.

Sutherland Discovered That Epinephrine Signals