What is the function of the release factor (RF)?
A) It separates tRNA in the A site from the growing polypeptide.
B) It binds to the stop codon in the A site in place of a tRNA.
C) It releases the amino acid from its tRNA to allow the amino acid to form a peptide bond.
D) It supplies a source of energy for termination of translation.
E) It releases the ribosome from the ER to allow polypeptides into the cytosol.

Question

Quizplus · Accepted Answer

The release factor (RF) binds to the stop codon in the A site, mimicking the shape of a tRNA. This triggers the hydrolysis of the polypeptide chain from the P-site tRNA, and the dissociation of the ribosomal subunits, leading to termination of translation.

What Is the Function of the Release Factor (RF)