Use the following information to answer the next few questions.
A transfer RNA (#1) attached to the amino acid lysine enters the ribosome. The lysine binds to the growing polypeptide on the other tRNA (#2) in the ribosome already.
-Which of the following mutations would be most likely to have a harmful effect on an organism?
A) a nucleotide-pair substitution
B) a deletion of three nucleotides near the middle of a gene
C) a single nucleotide deletion in the middle of an intron
D) a single nucleotide deletion near the end of the coding sequence
E) a single nucleotide insertion downstream of, and close to, the start of the coding sequence

Question

Quizplus · Accepted Answer

A single nucleotide insertion near the start of the coding sequence can cause a frameshift mutation, altering the reading frame and potentially leading to a nonfunctional protein, which is often harmful.

Use the Following Information to Answer the Next Few Questions