John Just Learned That Neither of the Gaseous Neurotransmitters (NO

John just learned that neither of the gaseous neurotransmitters (NO, CO) are produced in advance. Rather they are produced on demand for immediate release and action. John thinks it would be much more efficient if the body could make the free radical NO in advance and wants to look for a way to make this happen. What argument would convince him that this is not possible?

A) NO is made from lipids, so it can never be contained in a lipid vesicle.
B) NO is very reactive with oxygen and water, so it would not last in a vesicle.
C) NO is used in so few places, that it won't really make any difference metabolically.
D) NO is very reactive with lipids and would combine with the vesicle membrane to form a new compound.