Depletion of inositol 1,4,5-trisphosphate (IP₃) in the cytosol of a cell would A) lower cytosolic Ca²⁺ level B) opens voltage-gated Ca²⁺ channels C) activate G protein coupled receptors D) lower Ca²⁺ levels in the endoplasmic reticulum

Question

Quizplus · Accepted Answer

Inositol 1,4,5-trisphosphate (IP3) is involved in signaling pathways that lead to an increase in cytosolic Ca2+. Depletion of IP3 would result in a lower cytosolic Ca2+ level. It would not directly open voltage-gated Ca2+ channels or activate G protein-coupled receptors. It would also not affect Ca2+ levels in the endoplasmic reticulum.

Depletion of Inositol 1,4,5-Trisphosphate (IP3) in the Cytosol of a Cell

Depletion of Inositol 1,4,5-Trisphosphate (IP₃) in the Cytosol of a Cell