Dideoxynucleotides (DdNTPs, Shown Here Is Dideoxyguanosine) Are Nucleosides Lacking the 3'-Hydroxyl
Dideoxynucleotides (ddNTPs, shown here is dideoxyguanosine) are nucleosides lacking the 3'-hydroxyl group on their deoxyribose sugar. They are the key molecules for the method of DNA-sequencing, which was developed by Frederick Sanger in 1977. What is the function of dideoxynucleotides, based on its structure?
A) Dideoxynucleotides terminate DNA growth during replication at one distinct position.
B) Dideoxynucleotides terminate DNA growth statistically at each A-, G-, C- or T-site, depending on the dideoxynucleotides used (ddA, ddG, ddC or ddT) .
C) Dideoxynucleotides terminate the DNA replication and switch on DNA transcription to mRNA.
D) Dideoxynucleotides activate rRNA.
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