Azidothymidine (AZT) Is a Nucleoside Analog Reverse Transcriptase Inhibitor, Which

Azidothymidine (AZT) is a nucleoside analog reverse transcriptase inhibitor, which is an antiretroviral drug. It was the first drug approved for the treatment of HIV. AZT was the major breakthrough in AIDS therapy in the 1990's.

What is the function of AZT, based on its structure?

A) The azido-group (-N₃) facilitates irreversible binding to reverse transcriptase.
B) The azido-group (-N₃) facilitates irreversible binding to a neighboring nucleotide.
C) AZT cannot be incorporated into a DNA-strand during reverse transcription of the genetic code from RNA to DNA after retroviral infection.
D) All of the above