refers to an increase in the rate of the metabolism of a drug, so that the user must consume greater quantities of it in order to maintain a certain level of the drug in his or her body.

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Dispositional tolerance refers to an increase in the rate of metabolism of a drug, leading to a decrease in its effectiveness and requiring larger doses to achieve the desired effect. Functional tolerance, on the other hand, is when the user's brain becomes less sensitive or responsive to the drug's effects over time, leading to a decrease in its effectiveness. Cross tolerance refers to an individual's tolerance to one type of drug affecting their tolerance to another similar drug. Reverse tolerance, also known as sensitization, is when the user becomes more sensitive to the drug's effects over time, requiring smaller doses to achieve the desired effect.

Refers to an Increase in the Rate of the Metabolism