Which of the Following Statements Best Describes the Relationship Between

Which of the following statements best describes the relationship between the cultural practice of yam farming and a genetic mutation related to sickle-cell anemia?

A) Yam farming had environmental consequences that increased malaria rates, which in turn selected for the genetic mutation related to sickle-cell anemia.
B) Yam farming improved the quality of the local diet, which decreased malaria rates, and that in turn selected for the genetic mutation related to sickle-cell anemia.
C) The genetic mutation related to sickle-cell anemia compromised the average health of the population, leading people to farm yams in order to improve their diet.
D) The genetic mutation related to sickle-cell anemia protected people against malaria, allowing them to engage in sedentary agricultural practices such as yam farming.
E) Yam farming and the genetic mutation related to sickle-cell anemia arose separately, but each one influenced the other in a cycle of mutual constitution.