Factors that affect the pharmacokinetics of lipophilic medications in older adults include:

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Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat-soluble) medications can be stored thus resulting in a potential for an accumulation of the medication and potentially fatal overdoses. Older adults have a decrease in lean body mass and an increase in fat. An increased body mass would not affect lipophilic medication absorption. Older adults have a decreased glomerular filtration rate, which begins to decline as early as age 25. Older adults have a decrease in overall kidney function.

Factors That Affect the Pharmacokinetics of Lipophilic Medications in Older