Why Are Placebo Controls So Important in Antidepressant Clinical Trials

Why are placebo controls so important in antidepressant clinical trials?

A) Clinically significant improvements often occur in placebo-treated patients.
B) Antidepressant drugs have a high risk for dependency.
C) Placebos contain the inactive form of the antidepressant and are important for assessing safety risks.
D) Because participants rarely respond to the placebo, it provides a good baseline for comparing antidepressant effectiveness.