Which clinical phenotype is associated with a b-chain mutation that locks the hemoglobin into the relaxed state, which has a high affinity for oxygen?

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Polycythemia is associated with a mutation that locks hemoglobin in the relaxed state, leading to a higher affinity for oxygen. This results in less oxygen being released to tissues, which can trigger an increase in red blood cell production to compensate for the perceived lack of oxygen, a hallmark of polycythemia.

Which Clinical Phenotype Is Associated with a B-Chain Mutation That