Which of the following can help distinguish the combination Hemoglobin S (Hb S)$\beta$⁰-thalassemia from sickle cell anemia?

Question

Quizplus · Accepted Answer

Hb S is a structurally abnormal b globin chain;this gene is inherited from one parent.The $\beta$⁰ gene is inherited from the other parent,which means that no b chain production occurs from that gene.Thus the patient will not have any normal b chains to combine with a chains and form Hb A.The patient will have primarily Hb S,with an elevated Hb F,which is the same pattern seen in homozygous Hb S (i.e.,sickle cell anemia).However,in sickle cell anemia the red cells are normocytic,whereas in Hb S $\beta$⁰-thalassemia the red cells will be microcytic.

Which of the Following Can Help Distinguish the Combination Hemoglobin β\betaβ

Which of the Following Can Help Distinguish the Combination Hemoglobin $\beta$