Elevated urinary levels of 11-dehydrothromboxane B₂ identify patients who are

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11-Dehydrothromboxane B₂ is a metabolite derived from thromboxane A₂,synthesized by the platelet in the eicosanoid pathway.This pathway is blocked by aspirin's effect on cyclooxygenase.When it is not blocked,and platelet activation occurs,11-dehydrothromboxane B₂ is secreted and found in urine at an elevated level.Thus its elevation indicates that platelet activation is occurring and has not been blocked by aspirin.This is called aspirin resistance.

Elevated Urinary Levels of 11-Dehydrothromboxane B₂ Identify Patients Who Are