A 42-year-old man presents with a 1 * 1 cm white patch on the lateral surface of his tongue. Based solely on this information, clinical differential diagnosis should include:

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All the options listed are plausible differential diagnoses for a white patch on the tongue based on the information provided. Frictional hyperkeratosis can occur due to chronic irritation, hairy leukoplakia is often associated with Epstein-Barr virus (EBV) infection especially in immunocompromised individuals, and idiopathic leukoplakia represents a lesion with no identifiable cause and carries a risk of malignancy.

A 42-Year-Old Man Presents with a 1 * 1 Cm