Which factors are involved in the development of hypospadias? (Select all that apply.)
A)Disruption in male hormones, including testosterone
B)Mutation of gene HP-1 (chromosome 16)
C)5a-reductase mutations
D)Hormones administered for in vitro fertilization
E)Advanced maternal age

Question

Quizplus · Accepted Answer

The cause of hypospadias is multifactorial and related to disruptions in male hormones, including testosterone biosynthesis defects, 5a-reductase mutations, hormones administered for in vitro fertilization, advanced maternal age, and other environmental factors. A mutation of gene HP-1 (heterochromatin protein 1) gene is not relevant as this gene functions to form heterochromatin.

Which Factors Are Involved in the Development of Hypospadias? (Select