A biologic false-positive rheumatoid factor (RF) assay can be manifested by patients with

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Rheumatoid factor (RF) can be falsely positive in various conditions other than rheumatoid arthritis, including systemic lupus erythematosus (SLE), chronic infections like hepatitis and syphilis, among others. This is because RF, an antibody that targets the Fc portion of IgG, can be produced in a variety of inflammatory and infectious conditions, leading to false-positive results in these diseases.

A Biologic False-Positive Rheumatoid Factor (RF) Assay Can Be Manifested