Over time, barbiturate use results in upregulation of the enzymes responsible for the drug's breakdown. This phenomenon is known as enzyme __________________.

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Enzyme induction refers to the process where prolonged exposure to a drug leads to an increase in the production of enzymes that metabolize the drug, leading to a decrease in the drug's effectiveness over time. This is why barbiturate use results in upregulation of the enzymes responsible for the drug's breakdown.

Over Time, Barbiturate Use Results in Upregulation of the Enzymes