A 40-year-old man is participating in a clinical study on glucose clearance from the blood. He receives 25 grams of oral glucose; 1 hour later, the glucose load is completely cleared from the blood. He then receives 25 grams of intravenous glucose; 1 hour later, the glucose load is not cleared completely from the blood. This difference in glucose clearance following oral and intravenous administration can be attributed to the actions of which of the following hormones?

Question

Quizplus · Accepted Answer

Glucose-dependent insulinotropic peptide (GIP) is released in response to oral glucose and stimulates the release of insulin from pancreatic beta cells. This results in increased glucose uptake by tissues and clearance from the blood. However, with intravenous glucose administration, GIP release is not stimulated, leading to a slower clearance of glucose from the blood. Cholecystokinin, gastrin, motilin, and secretin are gastrointestinal hormones that do not play a major role in glucose clearance.

A 40-Year-Old Man Is Participating in a Clinical Study on Glucose