Assuming steady-state conditions and that water and electrolyte intake remained constant, a 75% loss of nephrons due to chronic kidney disease would cause all of the following except:

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A 75% loss of nephrons due to chronic kidney disease would cause a decrease in the ability of the kidney to maintain electrolyte and water balance, which can result in an increase in plasma creatinine (B) and phosphate (D) concentrations. The remaining nephrons would have to work harder to compensate for the loss, leading to an increase in the average volume excreted per remaining nephron (C) and a reduced ability of the kidney to maximally concentrate the urine (E). However, a large increase in plasma sodium concentration is unlikely as the kidney plays a crucial role in regulating sodium balance, and with a reduction in nephron function, there is a decreased ability to retain sodium, leading to hyponatremia rather than hypernatremia.

Assuming Steady-State Conditions and That Water and Electrolyte Intake Remained