An amino acid residue that is not part of the active site of an enzyme and does not interact with the ligand is nevertheless critical for ligand binding and is highly conserved. How can this be explained?
A) This residue is critical for the correct folding and the placement of ligand-binding site residues.
B) The residue helps with restricting the access of water to the ligand-binding site.
C) This residue can affect the chemical properties of the residues in the ligand-binding site.
D) All of the above.

Question

Quizplus · Accepted Answer

Residues that are far from the binding site can still influence ligand binding by affecting global or local folding of the protein, by controlling the access of water to the binding site, or by changing the chemical properties of other residues.

An Amino Acid Residue That Is Not Part of the Active