A DNA-binding protein binds cooperatively to DNA by fairly weak homodimerization. The binding of this protein to DNA …
A) shows a sigmoidal binding curve.
B) occurs in more of an all-or-none manner, compared to a protein that is a constitutive dimer.
C) occurs despite the fact that the protein molecules are predominantly monomers in solution.
D) All of the above.

Question

Quizplus · Accepted Answer

Cooperative binding creates a sigmoidal binding curve with two main states: at low protein concentrations, the protein is mostly a monomer and the binding site on DNA is mostly unoccupied; at high protein concentrations, the great majority of the DNA sites are occupied by the protein dimer.

A DNA-Binding Protein Binds Cooperatively to DNA by Fairly Weak