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You Have Engineered the X Chromosomes in Female Mice Such

Question 21

Multiple Choice

You have engineered the X chromosomes in female mice such that one X chromosome expresses green fluorescent protein when active, while the other expresses red fluorescent protein. You have used these mice to study cancer in females. You know that each tumor is a clonal cellular proliferation, meaning all of its proliferating cells are descendants of a single original cancer-causing cell. It follows that, unless X-chromosome inactivation is perturbed in tumors, …


A) all tumor cells in one mouse should express the same fluorescent protein (either red or green) , but tumor cells from different mice can show either red or green fluorescence.
B) the cells in any tumor should all express the same fluorescent protein (either red or green) , but independently derived tumors in the same mouse can show either green or red fluorescence.
C) different cells within each tumor can express different fluorescent proteins, and the tumors would therefore show yellow fluorescence, but each cell shows either red or green fluorescence.
D) each cell can express both fluorescent proteins and would therefore emit yellow fluorescence, and the tumors would glow in yellow as well.
E) different tumors would show red, yellow, or green fluorescence.

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