Two transcription activators cooperate to recruit a coactivator to a cis-regulatory sequence and activate transcription of a nearby gene. If each of the activators increases the affinity of the coactivator for the reaction site (and therefore the rate of transcription) by 100-fold, how much would you expect the affinity to increase when both activators are bound to DNA compared to when none is bound?
A) 10-fold
B) 100-fold
C) 200-fold
D) 10,000-fold

Question

Quizplus · Accepted Answer

The combined effect of two transcription activators binding to the same regulatory sequence in DNA is synergistic, not simply additive.

Two Transcription Activators Cooperate to Recruit a Coactivator to a Cis-Regulatory