How are antibody-producing hybridoma cell lines immortalized to provide an unlimited source of monoclonal antibodies?
A) By ectopic expression of telomerase
B) By transformation with a retrovirus
C) By cell fusion
D) By overproduction of introduced oncogenes
E) By irradiation

Question

Quizplus · Accepted Answer

Fusion of B cell clones with immortalized myeloma cells (a transformed B cell line) creates hybrid cells that are also capable of indefinite proliferation.

How Are Antibody-Producing Hybridoma Cell Lines Immortalized to Provide an Unlimited