Consider the transcriptional circuits depicted in the following schematic drawings. These circuits share identical kinetic parameters but have a different number of stages. Which circuit (A or B) creates more robust oscillations? Write down A or B as your answer.

Question

Quizplus · Accepted Answer

The circuit with more components (B) is more likely to oscillate compared to the similar circuit with fewer components. This is because an increase in the number of components in a negative feedback loop leads to delays in the amount of time required for the cycle of signals to be completed. The system with the longer loop also tends to exhibit stable oscillations within a much broader range of parameters, indicating that this system provides a more robust oscillator.

Consider the Transcriptional Circuits Depicted in the Following Schematic Drawings