Neuromuscular transmission involves the sequential activation of several ion channels. Sort the following events to reflect the sequence leading to muscle contraction. Your answer would be a five-digit number composed of numbers 1 to 5 only, e.g. 12543.
(A) Opening of voltage-gated Na? channels in the muscle cell plasma membrane.
(B) Opening of Ca²⁺ release channels in the sarcoplasmic reticulum membrane.
(C) Opening of ionotropic acetylcholine receptors on the muscle cell plasma membrane.
(D) Opening of voltage-gated Ca²⁺channels in the T tubules.
(E) Opening of voltage-gated Ca²⁺channels in the motor neuron.

Question

Quizplus · Accepted Answer

This sequence of events connects the arrival of the action potential at the axon terminal at a neuromuscular junction to the calcium-dependent contraction of muscle fibers.

Neuromuscular Transmission Involves the Sequential Activation of Several Ion Channels