Sort the following events in a sequence that would lead to long-term potentiation (LTP). Your answer would be a five-digit number composed of numbers 1 to 5 only, e.g. 13245.
(A) Activation of AMPA receptors
(B) Glutamate release into the synaptic clefts
(C) Activation of calcium-dependent protein kinases in the postsynaptic cell
(D) Postsynaptic membrane depolarization
(E) Activation of NMDA receptors

Question

Sort the following events in a sequence that would lead to long-term potentiation (LTP). Your answer would be a five-digit number composed of numbers 1 to 5 only, e.g. 13245.
(A)	Activation of AMPA receptors
(B)	Glutamate release into the synaptic clefts
(C)	Activation of calcium-dependent protein kinases in the postsynaptic cell
(D)	Postsynaptic membrane depolarization
(E)	Activation of NMDA receptors

Quizplus · Accepted Answer

The excitatory neurotransmitter glutamate released by an activated presynaptic axon terminal opens AMPA-receptor channels allowing Na? influx. This depolarizes the postsynaptic membrane, removing Mg²⁺ block from NDMA-receptor channels which, when bound to glutamate, allow Ca²⁺ to enter the cell and activate downstream pathways.

Sort the Following Events in a Sequence That Would Lead