Tom40 is a nuclear-encoded essential subunit of the TOM complex in the outer mitochondrial membrane. It is a ?-barrel protein that forms the pore through which precursor proteins enter the intermembrane space from the cytosol. Indicate true (T) and false (F) statements below regarding the Tom40 protein. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( ) Incorporation of new Tom40 in the outer membrane requires preexisting Tom40 in that membrane.
( ) Formation of new TOM complexes is dependent on the SAM complex.
( ) Tom40 is partially translocated through the outer membrane and is then transferred in the plane of the membrane to fold into its native conformation.
( ) Tom40 is translocated through the inner membrane as a precursor.

Question

Tom40 is a nuclear-encoded essential subunit of the TOM complex in the outer mitochondrial membrane. It is a ?-barrel protein that forms the pore through which precursor proteins enter the intermembrane space from the cytosol. Indicate true (T) and false (F) statements below regarding the Tom40 protein. Your answer would be a four-letter string composed of letters T and F only, e.g. TTTF.
( )	Incorporation of new Tom40 in the outer membrane requires preexisting Tom40 in that membrane.
( )	Formation of new TOM complexes is dependent on the SAM complex.
( )	Tom40 is partially translocated through the outer membrane and is then transferred in the plane of the membrane to fold into its native conformation.
( )	Tom40 is translocated through the inner membrane as a precursor.

Quizplus · Accepted Answer

Being a ?-barrel protein, the import and integration of Tom40 (and therefore the TOM complex) depend on functional TOM and SAM complexes.

Tom40 Is a Nuclear-Encoded Essential Subunit of the TOM Complex