Indicate whether each of the following descriptions better applies to COPI- (1), COPII- (2), or clathrin- (3) coated vesicles. Your answer would be a four-digit number composed of digits 1 to 3 only, e.g. 1322.
( ) They mediate transport from the ER to the cis Golgi network.
( ) Their coat protein forms a three-legged structure called a triskelion.
( ) They are pinched off from their donor compartment by a dynamin collar.
( ) They are involved in retrograde transport in the Golgi apparatus.

Question

Indicate whether each of the following descriptions better applies to COPI- (1), COPII- (2), or clathrin- (3) coated vesicles. Your answer would be a four-digit number composed of digits 1 to 3 only, e.g. 1322.
( )	They mediate transport from the ER to the cis Golgi network.
( )	Their coat protein forms a three-legged structure called a triskelion.
( )	They are pinched off from their donor compartment by a dynamin collar.
( )	They are involved in retrograde transport in the Golgi apparatus.

Quizplus · Accepted Answer

Typically, transport vesicles from ER to CGN are COPII-coated, whereas retrograde transport in the Golgi apparatus is mediated by COPI-coated vesicles. Clathrin-coated vesicles are involved in traffic from the plasma membrane as well between the endosomal and Golgi compartments, and require dynamin for pinching off efficiently. Clathrin triskelions assemble into a basket-like cage that envelopes these budding vesicles.

Indicate Whether Each of the Following Descriptions Better Applies to COPI-